Malaria control efforts are thwarted by the development of resistance to the available drugs by P. falciparum. The search for alternative drugs should be a never ending exercise. This research was aimed at phytochemical screening and testing the inhibitory effect of Citrus aurantifolia (Leaf extracts) on the schizont maturation of Plasmodium falciparum. The inhibitory effect was studied using 96 well micro titer plates with each well loaded with 100?l of warm sterile Rosswell Park Memorial Institute 1640 medium, 50?l of blood medium mixture, 20?l red blood cells and 20?l serum. Twenty microliters (20?l) plant extracts of different solvents (water, ethanol, hexane, petroleum ether and chloroform) were added into 13 wells for each extract. In another 13 wells, 20?l of chloroquine solution was added. In control wells, 20?l of individual solvents (water, ethanol, hexane, petroleum ether and chloroform) were added. The micro titer plate was kept in the desiccator and a candle was lit. When the candle went off, the desiccator was placed in an incubator at 37.50C for 24 hours. After which the contents were harvested and form thick film smear on pre- labeled slides. In the phytochemical screening, the result revealed the presence of Tannins, Saponin, Alkaloids and Glycosides in the plant extracts of hexane, petroleum ether, chloroform, ethanol and water. Anthraquinone glycosides, cyanogenic glycosides and Saponin glycosides were only present in ethanol and water extracts. None of the flavonoids and cardiac glycoside was detected in any of the solvents extracts. The percentage inhibition of schizont maturation using different solvents of the leaf extract at various concentrations showed inhibition ranges as follows: 10.1%-51.4% for aqueous, 10.9%-56.0%for hexane, 8.1%-72.7% for chloroform, 7.6%-75.3% for petroleum ether and 8.1%-88.4 for ethanol and 6.4%-41.0% for chloroquine.