This research work presents the effect of irrigation by domestic wastewater on soil properties in Kofar Kware area in Sokoto State, Nigeria. Soil samples were collected at different point interval in the study area. The parameter such as pH, Soil salinity, Chloride, nitrate, and organic matter, was used to carry out various analyses in the laboratory. The results obtained from pH in domestic wastewater was 8.6 and might cause problem for the crops planted on such soil, likewise other parameters: soil salinity, chloride, nitrate, and organic matter were very low in content which might cause the crop yield improperly. It was concluded and recommended that the domestic wastewater should not be used for irrigation activities in Kofar-Kware Irrigation farm, Sokoto. Alternatively, adequate clean and portable water should be supplied to the irrigation farms to dilute the rate of acidic content in the farm. Keywords: Irrigation, Domestic, Wastewater, Properties