The study examines Occupational stress, psychological and Job performance of female Nurses in three selected Hospitals from the local government in Sokoto state. The questionnaire was adopted as the research instrument to elicit the needed data from 377 respondents. Smart PLS SEM 3.2.8 was used to analyze the data analysis collected. PLS is a second-generation statistical methodology developed to address the drawbacks of first-generation statistical methods, including Manova, Factor analysis, and Analysis of Variance. The results indicate a significant relationship between occupational stress, psychological well-being and Job performance. The paper also discusses implications, and suggestions for further studies are provided.