Drug abuse appears to be a common business among the youth in the past decades, with physical and mental health complications. Despite the known risks associated with the drugs, male and female continue using these drugs. This paper seeks to identify the factors influencing the prevalence of drug abuse among female students in tertiary institutions in Sokoto State using Umaru Ali Shinkafi Polytechnic as a case study. The research adopts descriptive survey of data collection through the distribution of structured questionnaires. Findings reveal the prevalence of female drug abusers with numerous predisposing factors including pathological family background, peer pressure, ignorance of the danger of drug abuse amongst others. The paper recommends the need to set-up guidance and counseling units across various tertiary institutions in the state with a view to facilitating proper withdrawal of suspected female students from the menace.